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Celiac disease,
a hereditary digestive disease that interferes with the absorption
of nutrients from food, affects about one in 250 Americans.
Currently there is no known treatment or cure, but researchers
have uncovered new findings that may lead to the first medical
treatment of the disease.
Researchers discovered
that a synthetic form of alpha-Melanocyte-Stimulating Hormone
(a-MSH) has an anti-inflammatory effect in celiac mucosa,
the inside lining of the intestinal tract that absorbs food
into the body.
A-MSH is a naturally
occurring molecule that modulates inflammatory and immune
responses. Presence of the molecule suggests a local reaction
of the molecule to control the inflammatory response of gliadin,
the subfraction of gluten that acts as a poison in people
with the disease.
People with celiac
disease cannot tolerate gluten, a protein that is found in
wheat, barley and rye. Gluten causes an immune reaction that
results in damage to the small intestine and malabsorption.
Celica disease sufferers must adhere to a strict, gluten-free
diet in order to avoid this reaction.
The positive results
may be used to determine ways to use the molecules clinically.
Researchers suggest that controlling the inflammatory responses
that are a major part of celiac disease and limiting the immunosuppression
could lead to the first medical treatment of the disease.
Science
Blog
February 19, 2003
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