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Moderate food and/or energy
(calorie) restriction delays age-related immune dysfunction and prolongs
life span in multiple animal models. The amount and type of dietary fat
though can also profoundly affect your life span.
Fish oils that contain omega-3
fats have potent anti-inflammatory properties. The researchers examined
the effect of a 40% overall reduction in intake of all dietary foods,
combined with substitution of fish oil for corn oil. Mice, which develop
fatal autoimmune renal disease, were used. The food-restricted and fish
oil diet maximally extended median life span in the mice to 645 days (versus.
494 days for the food-restricted corn oil diet).
Similarly, fish oil prolonged
life span in the eat as much as you would like mice to 345 days (versus
242 for the eat as much as you like corn oil diet).
The increased life span was
partially associated with decreased body weight, blunting renal proinflammatory
cytokine (interferon-gamma, interleukins-10 and -12 and tumor necrosis
factor-alpha) levels and lower nuclear factor-kappaB (NF-kappaB).
These findings demonstrate
the profound additive effects of food restriction and omega-3 fats in
prolonging life span in mice. These observations may have additional implications
in the management of obesity, diabetes, cancer and/or the aging process.
Journal
Nutrition October 2001 ;131(10):2753-60
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