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July 31 2002
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Calorie Restriction

 

Moderate food and/or energy (calorie) restriction delays age-related immune dysfunction and prolongs life span in multiple animal models. The amount and type of dietary fat though can also profoundly affect your life span.

Fish oils that contain omega-3 fats have potent anti-inflammatory properties. The researchers examined the effect of a 40% overall reduction in intake of all dietary foods, combined with substitution of fish oil for corn oil. Mice, which develop fatal autoimmune renal disease, were used. The food-restricted and fish oil diet maximally extended median life span in the mice to 645 days (versus. 494 days for the food-restricted corn oil diet).

Similarly, fish oil prolonged life span in the eat as much as you would like mice to 345 days (versus 242 for the eat as much as you like corn oil diet).

The increased life span was partially associated with decreased body weight, blunting renal proinflammatory cytokine (interferon-gamma, interleukins-10 and -12 and tumor necrosis factor-alpha) levels and lower nuclear factor-kappaB (NF-kappaB).

These findings demonstrate the profound additive effects of food restriction and omega-3 fats in prolonging life span in mice. These observations may have additional implications in the management of obesity, diabetes, cancer and/or the aging process.

Journal Nutrition October 2001 ;131(10):2753-60



Dr. Mercola Dr. Mercola's Comments:

Mice were used in this study, and no mice read this newsletter as far as I know, but their increased lifespan is still quite impressive, and suggestive. Mice whose food intake was reduced by 40% but whose diet included fish oil lived nearly 300% longer than mice who ate as much as they wanted and used omega-6 oils, like corn oil.

It is also interesting to note that calorie restriction has a more powerful influence than adding fish oils, which alone only increased lifespan expectancy by 40%. As may of you know, I am a major advocate of fish oil and omega-3 fats, but I am truly amazed at the profound effect of calorie restriction. If one adds calorie restriction to the mice already eating fish oil, their lifespan increased from 40% all the way up to 265%, a nearly six-fold increase.

I do believe that eating less is likely to be healthier for us in the long run. This is largely related to reductions in insulin levels, the major accelerant of aging.

Controlled energy restriction is the only regimen that has been shown in the laboratory to increase lifespan, and therefore may be the foundational requirement for proper diet.

This is one of the reasons why the juicing program works so well. It provides a relatively low calorie, dense nutrition that does not raise insulin levels. Another great whole food option is Living Fuel, which provides dense nutrition with low calories and a minimal insulin response, and is very convenient for those who are often on the go.

Related Articles:

Cut Calories, Add Fish Oil To Really Lengthen Life Span

Restrict Your Calories and Live Longer

Nibbling, Grazing and Frequent Meals

Eat More Frequently to Stay Healthy

Cutting Calories Can Increase Your Lifespan

Eating More Frequently May Lower Your Cholesterol

Less Calories Key to Keeping Muscle Tone as We Age

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