A nasty entourage of side effects accompanies every drug, and anti-TNF
drugs--used to treat rheumatoid arthritis (RA)--are no exception.
According to a study, as much as one-fourth of patients taking anti-TNF
drugs experience skin infections, allergic rashes or eczema.
Because anti-TNF drugs work by suppressing the immune system, they
can cause users to become more vulnerable to adverse skin conditions.
Specifically, these drugs work by switching off tumor necrosis factor
(TNF), which stimulates cells to produce the inflammation response
that contributes to pain and swelling of the joints. Unlike COX-2
painkillers that simply mask the symptoms of the problem, anti-TNF
drugs are claimed to target the cause and are called disease-modifying
drugs for this reason.
Yet due to the critical skin problems evoked by these RA "wonder
drugs," patients are merely exchanging one medical concern
for another [text in blue]. And experts are only contributing to
the rise of these harmful drugs, stating such side effects may not
be a bad pay-off for the benefits received.
Study Highlights Risks of Anti-TNF Drugs
Concerns regarding anti-TNF drugs stemmed from a study involving
some 300 patients suffering from RA; patients were being treated
with the drugs from one to 10 years. Findings revealed:
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Twenty-five percent of the patients developed a skin problem
resulting in a visit to the dermatologist.
-
Only 13 percent of RA patients in a similar group who didn't
take anti-TNF drugs visited a dermatologist during the same
time period.
-
Seven patients experienced such severe skin effects that they
stopped taking their anti-TNF drug altogether.
Arthritis
Research and Therapy April 4, 2005;7(3):R666-R676 (Free Full-Text
Article)
BBC
News April 3, 2005
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