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It is known that adding fish oil, which is rich in omega-3 fatty
acids with EPA and DHA, to your diet is reported to decrease several
markers of the immune system. However, whether it is EPA, DHA or
a combination of both that affects the functioning of the immune
system remains unclear.
To find out, a study was conducted to determine the immune system
effects of adding EPA-rich or DHA-rich oils to the diet of healthy
humans.
The study, which was a double blind parallel and placebo-controlled,
consisted of 42 healthy adults who were randomly chosen to receive
either placebo oil (olive oil), EPA-rich oil or DHA-rich oil for
a four-week period. Samples of blood were drawn before and after
taking the oil.
The results of the study showed that the effects of the EPA were
significantly different from the DHA. While those who took the DHA-rich
oil showed a decrease in T lymphocyte activation, which helps keep
virus-infected or malignant cells in check, there was no significant
change among the EPA-rich oil group.
Conclusions from the study revealed that the use of DHA supplementation,
but not EPA, restrained the T lymphocyte activation. It was also
discovered that neither EPA nor DHA significantly affected any other
area of the immune system.
American
Journal of Clinical Nutrition April 2004;79(4) 674-681
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