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Campaigns aimed
at cutting back the overuse of antibiotics in the United States
may be working, as research showed that U.S. doctors prescribed
fewer unnecessary antibiotics in the 1990s.
However, when a
drug is necessary doctors are now more likely to prescribe
expensive, "broad-spectrum" antibiotics. The use
of such antibiotics doubled in the past decade.
Broad-spectrum
antibiotics are useful to fight certain bacteria that are
often the cause of severe infections and cannot be treated
by narrow-spectrum antibiotics. These types of bacteria are
usually not involved in the common respiratory tract infections
treated in doctor’s offices.
As of 1999, broad-spectrum
antibiotics accounted for close to half of antibiotics prescribed
to adults and 40 percent of those prescribed to children,
according to research.
As with the overuse
of antibiotics to fight specific bacteria, the overuse of
broad-spectrum antibiotics can cause bacteria to become resistant
to the drugs. More efforts are needed to persuade doctors
to not over-prescribe broad-spectrum antibiotics, according
to researchers.
In the study, researchers
examined data on doctor visits from 1991 to 1992, 1994 to
1995 and 1998 to 1999.
Visits that resulted
in an antibiotic prescription dropped from 13 percent to 10
percent for adults and from 33 percent to 22 percent for children.
However, the use
of broad-spectrum agents increased from 24 percent to 48 percent
of antibiotic prescriptions in adults and from 23 percent
to 40 percent in children, according to the report.
The average cost
for broad-spectrum drugs, which include Zithromax, Biaxin,
quinolones and Augmentin, was over $50 for a seven-day supply
in 1999, compared with less than $5 per seven-day course for
some narrow-spectrum drugs.
Although antibiotics
only fight bacteria, not colds, which are commonly caused
by a virus, from 1998 to 1999 22 percent of adults and 14
percent of children who were prescribed a broad-spectrum antibiotic
received one to treat a common cold or other viral infection.
The increasing
reliance on broad-spectrum antibiotics could lead to a new
crisis in antibiotic resistance, according to researchers.
Annals
of Internal Medicine April 1, 2003;138:525-533,605-606
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