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Who was studied?
The researchers
studied about 50 men who were at risk for type 2 diabetes
and showed signs of insulin resistance, a condition that occurs
in pre-diabetic people. Type 2 diabetes is the most common
form of diabetes, and occurs when the body can't properly
use insulin. The men also had high levels of triglycerides
and LDL cholesterol, and low levels of HDL cholesterol.
How was the
study conducted?
There were four
daily regimens that lasted 6 weeks:
- Cholesterol-lowering
drug Lipitor and fish oil tablets
- Lipitor and
a placebo
- Fish oil tablets
and a placebo
- Two inactive
placebos
None of the regimens
improved insulin resistance, both statins and fish oil improved
the men's balance of blood fats.
How did the
statin therapy and fish oil work?
- Statin therapy:
This blocked the formation of cholesterol, which improved
the clearance of molecules called ApoB that carry the harmful
form of cholesterol in the blood.
- Fish oils:
These interrupted the making of triglycerides, which interfered
with the liver's production of a certain type of ApoB molecules.
Diabetes
August 2002;51:2377-2386
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