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A simple test can diagnose
a heart condition in emergency department patients and may help ensure
appropriate treatment.
Congestive heart failure
occurs when the heart loses the ability to pump efficiently, resulting
in fluid build-up in the body, including the lungs. Currently, it can
be difficult to distinguish whether shortness of breath is caused by such
buildup or some other problem.
Researchers
found that a rapid test
to check levels of a hormone called B-type natriuretic peptide (BNP) could
identify CHF patients.
In the new study, they investigated
whether the same test would be useful in identifying CHF in emergency
department patients and whether it could predict how the patients would
fare over a 6-month period.
BNP is a hormone secreted in
high levels by heart tissue when the organ is overloaded with pressure
and its volume is expanded. The hormone, which acts as a diuretic, or
a compound that causes the body to excrete excess fluid, helps return
conditions to normal.
The BNP test involves analyzing
a patient's blood sample with a special antibody that "lights
up" when it detects BNP. The amount of BNP can then be read, and
the results are available within 15 minutes.
To evaluate the test, the researchers
determined BNP levels of 325 patients who arrived at the emergency department
with shortness of breath.
The investigators followed
the patients for 6 months to see how well BNP levels would predict death
due to heart problems or other causes, admission to hospital and repeat
visits to the emergency department.
Patients with BNP levels that
were four times above normal had about a 51% chance of having another
bout of congestive heart failure or dying within the next 6 months.
But patients with levels that
were less than twice the normal amount had an "excellent prognosis,"
and had only a 2.5% chance of problems within the next 6 months.
All patients with symptoms
of CHF might benefit from this test. But patients with certain other health
problems, such as some types of lung disease or advanced kidney disease,
might have abnormally high levels of BNP that could interfere with the
reading.
This is an inexpensive
and rapid test that should be able to benefit anyone taking
care of a person with shortness of breath. The findings are enough to
advocate widespread use of the test.
Annals of Emergency Medicine
2002;39:138-145
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