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There are two major
factors known to contribute to osteoporosis -- peak bone mass
during childhood and adolescence and the rate of bone loss
during aging. Bone mineral density (BMD) and bone mineral
apparent density (BMAD) are used as measures of osteoporosis
and are the result of the process of bone formation and resorption.
Bone mass accumulates during childhood and early adulthood
and it is thought that during this time increased bone resorption
and decreased bone formation can reduce peak bone mass. Therefore,
it is important to identify contributors to skeletal development
in order to prevent osteoporosis.
One such contributor
may be Vitamin D, which can be obtained through diet or synthesized
in the skin after sun exposure. Vitamin D is commonly measured
by serum concentration of 25-hydroxyvitamin D (25(OH)D). Vitamin
D deficiency is common among children and adolescents, especially
when sunshine is scarce during the winter months. This can
lead to severe hypovitaminosis D.
A recent study,
which investigated the effects of vitamin D status on the
acquisition of BMD and BMAD, found a significant association
between the baseline concentration of 25(OH)D and BMD and
BMAD at the lumbar spine and femoral neck among peripubertal
girls. Girls with the highest baseline serum 25(OH)D, had
a BMD that increased 26 percent more than girls with the lowest
baseline serums; that of BMAD increased some 50 percent. Participants
whose baseline serum 25(OH)D was greater than 50 nmol/L did
not lose BMD at the lumbar spine, indicating that adequate
vitamin D is important during this phase of life, according
to researchers.
Researchers note
that dietary intake of vitamin D is not enough to maintain
optimal vitamin D levels during the winter months. In an unrelated
study, it was found that participants had less than optimal
vitamin D levels even during the summer months, when sun exposure
is generally greater.
The study suggests
that hypovitaminosis D during the pubertal stages of life,
when the growth of BMD is most rapid, is more harmful than
hypovitaminosis D at an earlier age. Researchers believe that
the later premenarcheal years are a crucial stage in preventing
osteoporosis.
Researchers believe
that the effect of vitamin D may be specific to certain areas,
as results showed a particular effect on the lumbar spine.
A previous study found that exposure to sunlight effected
BMD in prepubertal girls, with a more pronounced effect at
the spine than hip. Further evidence of site specific effects
were shown by another study that found an association between
BMD of the forearm and hypovitaminosis D in adolescents.
Participants in
the original study had generally low dietary vitamin D intakes
and low serum 25(OH)D values at the beginning of the three-year
study. They were given vitamin D supplements during the winter,
however, this had little effect on 25(OH)D concentration.
Physical activity
has been shown to have a strong effect on the growing skeleton.
To account for this, researchers adjusted BMD and BMAD values
for baseline bone density and amount of physical activity
over the three-year period.
Researchers concluded
that hypovitaminosis D has harmful effects on bone mineral
growth, particularly at the lumbar spine, during a period
of development when peak bone mass should be reached. They
say that vitamin D supplements should be considered during
the peripubertal years.
American
Journal Clinical Nutrition December 2002 76:1446-1453
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