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Infection with the ulcer-causing bacterium
Helicobacter pylori may increase a person's risk of developing
larynx cancer.
Approximately
two thirds of the world's population is infected with H. pylori.
In the United States, H. pylori is more
prevalent among older adults, African Americans, Hispanics
and people of lower socioeconomic status, according to the
Centers for Disease Control and Prevention (CDC).
In the study researchers checked for
H. pylori infection in 26 patients diagnosed with larynx cancer
and 32 cancer-free patients. About 73% of patients with larynx
cancer had H. pylori infection, the investigators found, while
41% of those without cancer were infected with the bacterium.
This study suggests that H. pylori may
be an initiator or promoter organism of larynx cancer. H.
pylori could make the cells lining the larynx more susceptible
to cancerous changes when they are exposed to substances known
to promote cancer, such as tobacco and alcohol.
According to the CDC, recent studies
have shown an association between long-term H. pylori infection
and the development of gastric, or stomach, cancer.
Gastric cancer is the second most common
cancer worldwide, and is most common in countries such as
Colombia and China, where H. pylori infects more than half
the population in early childhood. In the United States, where
H. pylori infection is less common among young people, gastric
cancer rates have decreased since the 1930s.
Cancer of the larynx is the most common
type of cancer to occur in the head and neck. Approximately
10,000 Americans will be diagnosed with the disease and roughly
4,000 people will die from it in 2001.
Otolaryngology-Head
and Neck Surgery November 2001;125:520-521
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